Multi-Omics Data on Fertility Status in Beef Heifers from Peripheral Blood Cells

230 differentially expressed genes and 70 differentially abundant proteins were identified from RNA-Seq and proteomic analysis of peripheral white blood cells from 12 beef heifers. The dataset, created by T. Cody Brown and last updated in April 2026, integrates transcriptomic and proteomic data to investigate molecular signatures associated with pregnancy outcomes. It includes results from over-representation and network analyses, highlighting pathways like chemokine signaling and JAK-STAT signaling.

Use Cases

• Identify potential fertility biomarkers based on differentially expressed genes and proteins.
• Analyze regulatory network rewiring patterns between fertile and subfertile groups.
• Investigate the interplay between hormone signaling and chromatin regulation using epigenetic transcription factor data.
• Validate multi-omics integration approaches for non-invasive biomarker discovery in cattle.

Strengths

• Integrates two omics layers (transcriptomics and proteomics) from the same biological samples.
• Includes results from specific statistical and network analyses (e.g., over-representation analysis, regulatory impact factor genes).
• Data is focused on a non-invasive sample source (peripheral white blood cells) for biomarker research.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (13.6 KB), indicating limited raw data, likely containing summary results only.
• Based on a sample of 12 heifers (6 per group), which is a limited cohort size.

Provenance

Source

T. Cody Brown via figshare.

Collection Method

RNA-Sequencing and untargeted proteomics on peripheral white blood cells collected before artificial insemination.

Time Range

The collection time is not specified in the description.

Freshness

Last updated 2026-04-19 22:01:29; freshness should be verified.

Geography

The geographic origin of the beef heifers is not specified.