Plasma Proteome Mendelian Randomization for Gastric Cancer Drug Targets

13 ancestry-specific plasma protein targets for gastric cancer, identified through Mendelian randomization analysis of European and East Asian populations. The dataset was authored by Peng Zhi and last updated on May 1, 2026. It includes four significant protein targets for the European population and nine for the East Asian population, with experimental validation results for NME4 and ICAM5.

Use Cases

• Identify ancestry-specific causal protein targets for gastric cancer based on Mendelian randomization results.
• Prioritize drug repurposing candidates based on molecular docking results, such as digoxin.
• Investigate cellular expression patterns of identified targets in epithelial and pit mucous cells from gastric tumor tissue.
• Validate tumor-suppressive or oncogenic functions of proteins like NME4 and ICAM5 using experimental data.

Strengths

• Identifies 13 specific protein targets, including five novel candidates, for gastric cancer.
• Provides ancestry-stratified results for European (4 targets) and East Asian (9 targets) populations.
• Includes experimental validation data for NME4 and ICAM5 in cell lines and tissue samples.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic bias inherent to the source populations studied.

Provenance

Source

figshare

Collection Method

Mendelian randomization and colocalization analysis of plasma proteome data, supplemented by single-cell RNA sequencing, molecular docking, and experimental validation.

Freshness

Last updated 2026-05-01 04:19:32; freshness should be verified.

Geography

European and East Asian populations.