Platycodin D Effects on Cardiac Hypertrophy and Apoptosis Signaling in Mice

A 22.0 KB Excel dataset from a 2026 study by Yingrui Li on figshare. It contains results from a mouse model of isoprenaline-induced heart failure, investigating the therapeutic effects of Platycodin D. The data likely includes measurements related to cardiac function, hypertrophy, and the p53-dependent BCL-2/Bax/caspase-3 signaling pathway.

Use Cases

• Analyzing dose-response relationships of Platycodin D based on the described 12.5, 25, and 50 mg/kg/d treatment groups.
• Modeling the inhibition of the p53-mediated apoptotic pathway based on the described BCL-2/Bax/caspase-3 signaling data.
• Comparing therapeutic effects between Platycodin D and the p53 inhibitor pifithrin-α based on the described pharmacological interventions.

Strengths

• Dataset is openly licensed under CC-BY-4.0.
• Study design includes specific dose levels (12.5, 25, 50 mg/kg/d) and a 4-week treatment period.
• Research investigates a specific molecular mechanism (p53-dependent BCL-2/Bax/caspase-3 pathway).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Dataset is very small at 22.0 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Experimental data from a mouse model study, likely including results from network pharmacology, molecular docking, and pharmacological interventions.

Freshness

Last updated 2026-05-26 06:03:51; freshness should be verified.