Retinoic Acid Antiviral Effects on Porcine Respiratory Virus

Figshare data from Jintong Guo's 2026 study explores the antiviral efficacy of all-trans retinoic acid (ATRA) against porcine reproductive and respiratory syndrome virus (PRRSV). The dataset contains transcriptomic profiling results from porcine alveolar macrophages (PAMs) under infected and uninfected conditions. It details how ATRA treatment inhibits viral replication by modulating immune signaling and metabolic pathways.

Use Cases

• Analyze transcriptomic data to identify genes upregulated by ATRA treatment in uninfected PAMs.
• Compare gene expression profiles between PRRSV-infected and ATRA-treated PAMs to study inflammation suppression.
• Investigate the relationship between ATRA treatment and lipid homeostasis pathways disrupted by PRRSV infection.

Strengths

• Data is directly linked to a peer-reviewed experimental study on a major swine pathogen.
• Includes comparative transcriptomic profiles for both uninfected and PRRSV-infected cell conditions.
• Dataset is openly available under a CC BY 4.0 license for reuse.

Limitations

• The dataset is small at 102.8 KB, indicating limited scope, likely summary statistics rather than raw sequencing data.
• Sample size and specific row/column counts for the underlying measurements are not provided.
• Data is specific to in vitro cell models (MARC-145 cells and PAMs), limiting direct extrapolation to whole organisms.

Provenance

Source

Jintong Guo via Figshare.

Collection Method

Generated from laboratory experiments evaluating ATRA efficacy and subsequent transcriptomic profiling.

Time Range

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Freshness

Last updated in March 2026.

Geography

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