Sea Urchin Immune Cell Transcriptional Response to UVB-Induced DNA Damage

Transcriptomic data from purple sea urchin immune cells exposed to UVB radiation, collected by Riss M. Kell. The dataset likely contains gene expression profiles from single-cell RNA sequencing at six hours post UVB exposure. The work was published on figshare in March 2026.

Use Cases

• Identify conserved DDR gene activation based on transcriptional response data
• Analyze autophagy pathway induction based on functional assay results
• Compare innate immune pathway activation between phagocytes and vibratile cells based on single-cell RNA sequencing
• Investigate post-translational modifications (ubiquitination and phosphorylation) in key signaling pathways based on western blot data

Strengths

• Data is derived from single-cell RNA sequencing, providing cell-type-specific resolution.
• Includes functional assay and western blot validation of transcriptional findings.
• Focuses on a long-lived, cancer-resistant basal deuterostome model (Strongylocentrotus purpuratus).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect experimental bias inherent to the specific UVB exposure protocol.

Provenance

Source

figshare

Collection Method

Experimental study using UVB exposure, single-cell RNA sequencing, functional assays, and western blotting.

Freshness

Last updated 2026-03-19 05:18:32