Plasma Exosomal Protein Profiles for Intrahepatic Cholestasis of Pregnancy

A proteomic dataset from figshare, authored by Yuxuan Jiang and last updated in April 2026. It contains quantitative protein profiles from plasma exosomes of 35 pregnant women, including 10 with moderate intrahepatic cholestasis of pregnancy (ICP), 10 with severe ICP, and 15 healthy controls. The data likely includes differentially expressed proteins identified via SWATH proteomics and bioinformatics analysis.

Use Cases

• Identify diagnostic protein biomarkers for ICP severity based on differentially expressed proteins.
• Investigate complement activation and blood coagulation pathways in ICP pathology.
• Validate hub protein candidates like HRG, VWF, and PIGR using the provided quantitative data.
• Compare protein profiles between total exosomes and placenta-derived exosomes.

Strengths

• Data is derived from a controlled study with 35 patient samples across three groups.
• SWATH proteomics identified 109 and 46 differentially expressed proteins in two exosome types.
• The dataset includes bioinformatics analysis revealing involvement in complement activation, coagulation, and stress responses.
• Key hub proteins (HRG, VWF, PIGR) were verified by Western blotting.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (18.9 KB), indicating limited scope.

Provenance

Source

figshare, author Yuxuan Jiang.

Collection Method

Sequential window acquisition of all theoretical fragment ions (SWATH) proteomics performed on plasma exosomes.

Freshness

Last updated 2026-04-10 06:00:53; freshness should be verified.