NDRG4 Gene Methylation in Blood Leukocytes and Association with Gastric Cancer

Two-phase case-control study of 610 individuals (310 gastric cancer patients and 300 controls) analyzed the association between NDRG4 gene methylation in blood and cancer risk. The research, authored by Zhan Li and last updated in April 2026, found specific CpG sites correlated with cancer risk, chemotherapy efficacy, and patient survival. Bioinformatics analysis of TCGA and GEO databases was used to study the NDRG gene family's expression and methylation patterns.

Use Cases

• Predicting gastric cancer risk based on methylation levels at specific NDRG4 CpG sites mentioned in the study
• Analyzing the association between NDRG4 gene methylation and chemotherapy efficacy in gastric cancer patients
• Studying the relationship between NDRG4 methylation and progression-free survival (PFS) prognosis
• Investigating how the rs7202037 SNP genotype influences NDRG4 gene methylation levels

Strengths

• Includes data from a two-phase case-control study with 610 total participants
• Reports specific odds ratios and p-values for associations (e.g., OR=2.536 for site chr16:58497239)
• Integrates findings from public bioinformatics databases (TCGA and GEO)

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is very small (20.0 KB), indicating limited scope, likely containing summary results rather than raw data

Provenance

Source

figshare, author Zhan Li

Collection Method

Case-control study and bioinformatics analysis of public databases (TCGA, GEO)

Freshness

Last updated 2026-04-27 04:12:23; freshness should be verified