Lung Adenocarcinoma Prognostic Genes from Single-Cell and Mendelian Randomization Analysis

A figshare dataset by Jiaxin Li, last updated March 2026, containing results from an integrated analysis of lung adenocarcinoma. The data identifies seven prognostic genes associated with endoplasmic reticulum stress and butyrate metabolism, validated via RT-qPCR in non-small cell lung cancer cell lines. The 147.3 KB file includes a risk model, nomogram, and immune microenvironment profiling results.

Use Cases

• Validating prognostic gene signatures for lung adenocarcinoma based on the seven identified genes (VDAC1, TXNRD1, GDF15, TRIB3, LPL, KCNQ1, PKP2).
• Building or benchmarking survival prediction models based on the described risk model and nomogram for 1-, 3-, and 5-year survival.
• Analyzing immune microenvironment composition in lung cancer based on the 13 differentially abundant immune cell types identified, including M1 macrophages.
• Investigating pathway enrichment in high- vs. low-risk patient groups based on pathways like olfactory transduction, ribosome, and complement-coagulation cascades.

Strengths

• Identifies seven specific prognostic genes (VDAC1, TXNRD1, GDF15, TRIB3, LPL, KCNQ1, PKP2) with expression validated by RT-qPCR.
• Risk model and nomogram were constructed and demonstrated predictive accuracy for 1-, 3-, and 5-year survival outcomes.
• Analysis includes results from single-cell transcriptomics, Mendelian randomization, and immune profiling of 13 cell types.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is small (147.3 KB), suggesting it contains summary results rather than raw sequencing or individual patient data.
• Geographic and demographic context for the underlying public datasets is not specified, which may limit generalizability.

Provenance

Source

figshare, author Jiaxin Li.

Collection Method

Integrated analysis of public datasets using weighted gene co-expression network analysis, differential expression, and Mendelian randomization.

Freshness

Last updated 2026-03-25 22:03:02.