H1N1 Hemagglutinin Mutations and Co-Detection Evidence Map (2000–2025)

11,848 unique publications and GenBank-derived hemagglutinin sequences were analyzed to map the evolutionary trajectory of influenza A(H1N1) from 2000 to 2025. The study, authored by Xinrui Cao and published in 2026, integrates bibliometric analysis, expert curation, and structural modeling of viral proteins. It identifies a post-2010 shift in the HA mutational landscape and reports frequent co-detections with pathogens like RSV and SARS-CoV-2.

Use Cases

• Identify recurrent HA mutational sites like S13, S146, S160, and S202 for tracking viral evolution.
• Analyze the conformationally flexible HA segment spanning residues aa190–aa226 for structural studies on receptor binding.
• Map literature-derived co-detection records to understand reporting patterns for pathogens like RSV and SARS-CoV-2.
• Prioritize specific mutations like G219A in Eurasian avian-like H1N1 strains for hypothesis generation in receptor-binding research.
• Use the integrated bibliometric and sequence evidence to inform method-aware, multi-pathogen surveillance frameworks.

Strengths

• Analysis based on 11,848 unique, deduplicated publications from major databases.
• Integrates multiple data types: bibliometric records, HA sequences from GenBank, and homology models from Swiss-Model.
• Covers a 25-year temporal range from 2000 to 2025 for longitudinal trend analysis.

Limitations

• The dataset is a 516.0 KB DOC file, limiting direct computational analysis and requiring manual text extraction.
• Co-detection records are derived from heterogeneous literature and do not represent population-level prevalence.
• Specific sample sizes for sequence data or row counts for structured data are not provided.

Provenance

Source

figshare, authored by Xinrui Cao.

Collection Method

Evidence-mapping synthesis integrating bibliometric analysis of PubMed, Web of Science, and Scopus, expert-guided curation, and sequence/structure-informed interpretation.

Time Range

2000–2025

Freshness

Last updated March 2026, providing a current synthesis.

Geography

Global scope with a specific China-focused module for certain strain analysis.