Bordetella Pertussis Macrolide Resistance Trajectories Under Erythromycin Exposure

Kaichong Jiang published this dataset on 2026-04-17. It contains experimental results tracking the evolution of macrolide resistance in three clinical Bordetella pertussis isolates under stepwise erythromycin exposure. The data includes genomic and phenotypic measurements such as minimum inhibitory concentrations, growth assays, and ELISA readouts for virulence factors.

Use Cases

• Modeling antibiotic resistance trajectories based on genetic background and phenotypic readouts mentioned in the description
• Analyzing correlations between genomic alterations and changes in minimum inhibitory concentration (MIC) described in the results
• Comparing differences in growth and biofilm formation across bacterial lineages under antibiotic exposure as detailed in the study

Strengths

• Data is associated with a detailed methodological description of stepwise erythromycin induction and whole-genome sequencing.
• Includes multiple phenotypic readouts such as antimicrobial susceptibility testing, growth assays, and ELISA-based measurements as described.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small at 15.8 KB, indicating limited scope.

Provenance

Source

figshare, author Kaichong Jiang

Collection Method

Data was generated via stepwise erythromycin induction of three clinical Bordetella pertussis isolates, with tracking via whole-genome sequencing and phenotypic assays.

Freshness

Last updated 2026-04-17 05:20:54; freshness should be verified.