Platycodin D Effects on Cardiac Hypertrophy and Apoptosis Signaling in Mice

A 10.1 KB dataset from a 2026 study by Yingrui Li, shared on figshare under a CC-BY-4.0 license. It contains results from a mouse model of isoprenaline-induced heart failure, investigating the therapeutic effects of Platycodin D. The data likely includes measurements related to cardiac function, hypertrophy, and the p53-dependent BCL-2/Bax/caspase-3 signaling pathway.

Use Cases

• Analyzing dose-response relationships of Platycodin D on cardiac function based on the described 12.5, 25, and 50 mg/kg/d treatments.
• Investigating correlations between p53 inhibition and apoptosis markers like Bcl-2/Bax/caspase-3 as suggested by the described signaling pathway.
• Comparing therapeutic effects of Platycodin D against the p53 inhibitor pifithrin-α (PFT-α) as referenced in the study methodology.
• Modeling the role of network pharmacology-identified targets, such as p53, in cardiac hypertrophy treatment.

Strengths

• Data is associated with a specific, peer-reviewed experimental study described in detail.
• Includes results from a dose-response study with three distinct treatment levels (12.5, 25, 50 mg/kg/d).
• Shared under a permissive CC-BY-4.0 license for reuse.

Limitations

• The dataset is very small at 10.1 KB, indicating limited scope or summary-level data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for statistical analysis.

Provenance

Source

figshare, author Yingrui Li.

Collection Method

Experimental data from a mouse model study, likely involving biological assays and network pharmacology analysis.

Freshness

Last updated 2026-05-26 06:03:51; freshness should be verified.