Retinoic Acid Transcriptomic Effects on Porcine Macrophages and PRRSV

46.2 KB Excel file contains transcriptomic data from a study on retinoic acid's antiviral effects against porcine reproductive and respiratory syndrome virus. Jintong Guo published the dataset in 2026, detailing results from experiments on MARC-145 cells and primary porcine alveolar macrophages. The data supports findings that all-trans retinoic acid inhibits viral infection and modulates inflammatory and metabolic pathways.

Use Cases

• Analyze transcriptomic profiles from PRRSV-infected and uninfected porcine alveolar macrophages to identify differentially expressed immune signaling genes.
• Compare lipid homeostasis pathway alterations between ATRA-treated and untreated infected cells using transcriptomic data.
• Investigate the correlation between ATRA-induced gene upregulation in metabolic transport pathways and the suppression of non-specific inflammatory activity.

Strengths

• Dataset is published under a permissive CC BY 4.0 license, allowing broad reuse.
• Data originates from a 2026 study, ensuring recent scientific relevance.
• Transcriptomic profiling includes both uninfected and PRRSV-infected cell conditions for comparative analysis.

Limitations

• The dataset is very small at 46.2 KB, indicating limited scope and likely a summary of experimental results rather than raw sequencing data.
• Specific row counts, column structures, and sample data are unavailable, hindering immediate analytical utility.
• Data is confined to in vitro cell models (MARC-145 and PAMs), limiting direct extrapolation to in vivo porcine health.

Provenance

Source

Jintong Guo via figshare.

Collection Method

Generated from transcriptomic profiling of porcine alveolar macrophages under PRRSV infection and ATRA treatment conditions.

Freshness

Last updated March 2026.