Plasma Exosomal Proteins in Intrahepatic Cholestasis of Pregnancy

SWATH proteomics identified 109 and 46 differentially expressed proteins in plasma exosomes from 35 pregnant women, including 10 with moderate intrahepatic cholestasis, 10 with severe cases, and 15 healthy controls. The dataset, created by Yuxuan Jiang and last updated in April 2026, contains bioinformatics analysis results for proteins like HRG, VWF, and PIGR. These proteins are implicated in complement activation, blood coagulation, and stress responses associated with the gestational liver disorder.

Use Cases

• Identifying potential diagnostic biomarkers for intrahepatic cholestasis of pregnancy based on differentially expressed proteins.
• Analyzing protein pathways involved in complement activation and blood coagulation in pregnancy disorders.
• Comparing protein expression profiles between total exosomes and placenta-derived exosomes.
• Validating hub protein candidates like HRG, VWF, and PIGR for further experimental study.
• Investigating the fetal stress response and release of procoagulant factors in maternal blood.

Strengths

• Data is derived from a controlled study with 35 patient samples across three groups.
• Proteomic analysis identified 109 and 46 specific differentially expressed proteins.
• Bioinformatics analysis links proteins to specific biological processes like complement activation.
• Dataset is openly licensed under CC-BY-4.0.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The dataset is very small (17.5 KB), indicating limited scope.
• Data may reflect bias inherent to the specific clinical study sample.

Provenance

Source

figshare

Collection Method

Quantitative proteomic profiling using SWATH proteomics on plasma exosomes.

Freshness

Last updated 2026-04-10 06:00:52; freshness should be verified.