Influenza A(H1N1) Hemagglutinin Mutations and Co-Detection Records (2000–2025)

A bibliometric and sequence analysis dataset synthesizes 11,848 unique publications and GenBank-derived hemagglutinin sequences for influenza A(H1N1) from 2000 to 2025. The work, authored by Xinrui Cao and updated in March 2026, maps evolutionary trajectories, specific mutational sites, and reported co-detection patterns with other pathogens like RSV and SARS-CoV-2.

Use Cases

• Analyze the post-2010 shift in hemagglutinin mutational landscape using data on recurrent substitutions at sites like S13, S146, S160, and S202.
• Investigate the conformationally flexible HA segment spanning residues aa190–aa226 for structural studies of the receptor-binding microenvironment.
• Map literature-derived co-detection patterns to identify frequently reported co-pathogens such as RSV and SARS-CoV-2 across heterogeneous studies.
• Examine the China-focused module's expert-annotated data on the G219A mutation in Eurasian avian-like H1N1 strains as a hypothesis-generating site.
• Use the integrated bibliometric records to track research evolution and surveillance priorities for influenza A(H1N1) over a 25-year period.

Strengths

• Integrates a large corpus of 11,848 unique publications from major databases like PubMed, Web of Science, and Scopus.
• Covers a 25-year temporal range (2000–2025) for tracking evolutionary and research trends.
• Combines multiple data types: bibliometric records, GenBank-derived HA sequences, and Swiss-Model homology structures.

Limitations

• The dataset is very small at 11.2 KB, indicating it contains summary or aggregated data rather than raw sequence or publication records.
• Co-detection records are derived from heterogeneous literature and reflect reporting composition, not population-level prevalence, introducing potential bias.
• Specific row counts and column details for the tabular data are unknown, limiting assessment of granularity and sample size.

Provenance

Source

figshare, authored by Xinrui Cao.

Collection Method

Evidence-mapping synthesis integrating bibliometric analysis of retrieved publications, expert-guided curation, and sequence/structure-informed interpretation using GenBank and Swiss-Model.

Time Range

2000–2025

Freshness

Last updated March 2026, indicating recent curation.

Geography

Global focus with a specific module on China.