SWATH proteomics identified 109 and 46 differentially expressed proteins in total and placenta-derived exosomes from plasma samples of 35 pregnant women, including 10 with moderate intrahepatic cholestasis of pregnancy (ICP), 10 with severe ICP, and 15 healthy controls. The dataset was created by Yuxuan Jiang and last updated on April 10, 2026. Bioinformatics analysis revealed proteins involved in complement activation, blood coagulation, and stress responses.
Use Cases
- Identify diagnostic protein markers for ICP severity based on differential expression in exosomes
- Analyze biological pathways like complement activation and coagulation implicated in ICP pathology
- Validate hub protein candidates such as HRG, VWF, and PIGR using proteomic data
Strengths
- SWATH proteomics identified 109 differentially expressed proteins in total exosomes and 46 in placenta-derived exosomes
- Data is derived from plasma samples of 35 pregnant women across three clinical groups
- Hub proteins HRG, VWF, and PIGR were identified and verified by Western blotting
Limitations
- Row count is unknown, which may limit suitability assessment
- Column-level documentation is absent; field semantics must be inferred after download
- The dataset is 14.5 KB, indicating a limited scope of data
Provenance
- Source
- figshare
- Collection Method
- Sequential window acquisition of all theoretical fragment ions (SWATH) proteomics performed on plasma exosomes.
- Freshness
- Last updated 2026-04-10 06:00:52