Transcriptomic Effects of Retinoic Acid on PRRSV-Infected Porcine Macrophages

A research article analyzes the antiviral efficacy of all-trans retinoic acid (ATRA) against Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). The study includes transcriptomic profiling data from primary porcine alveolar macrophages (PAMs) under uninfected, PRRSV-infected, and ATRA-treated conditions. The author is Jintong Guo, with the article last updated in March 2026.

Use Cases

• Analyze transcriptomic profiles from uninfected and PRRSV-infected PAMs to identify hyperinflammatory response signatures.
• Compare RNA-seq data from ATRA-treated versus untreated PAMs to study the regulation of immune signaling and metabolic transport pathways.
• Investigate the reversal of lipid homeostasis disruption in infected PAMs following ATRA treatment using transcriptomic data.

Strengths

• Data originates from controlled in vitro experiments in two cell types: MARC-145 cells and primary porcine alveolar macrophages (PAMs).
• Transcriptomic profiling provides a detailed molecular view of host responses to both PRRSV infection and ATRA treatment.
• The dataset is openly shared under a CC BY 4.0 license, permitting reuse with attribution.

Limitations

• The primary data is a 22.2 KB DOCX file containing a research article, not a structured, machine-readable dataset of rows and columns.
• No raw RNA-seq data files, gene expression matrices, or sample metadata tables are provided in the input.
• The scope is limited to the specific experimental findings described in the single article.

Provenance

Source

Jintong Guo via figshare.

Collection Method

In vitro experiments evaluating ATRA's antiviral efficacy, followed by transcriptomic profiling via RNA sequencing.

Freshness

Last updated March 2026.