SWATH proteomics identified 109 and 46 differentially expressed proteins in plasma exosomes from pregnant women. The dataset contains quantitative proteomic profiles from 35 pregnant women, including 10 with moderate intrahepatic cholestasis of pregnancy (ICP), 10 with severe ICP, and 15 healthy controls. The data was published by Yuxuan Jiang on figshare in April 2026.
Use Cases
- Identify diagnostic biomarkers for ICP severity based on differentially expressed proteins.
- Analyze complement activation and blood coagulation pathways in ICP pathology.
- Validate hub protein candidates like HRG, VWF, and PIGR using proteomic data.
- Investigate fetal stress response mechanisms linked to maternal bile acid levels.
- Compare protein profiles between total exosomes and placenta-derived exosomes.
Strengths
- Includes proteomic data from 35 patient samples across three clinical groups.
- Identifies 109 and 46 specific differentially expressed proteins in two exosome types.
- Bioinformatics analysis links proteins to complement activation, coagulation, and stress responses.
- Hub proteins HRG, VWF, and PIGR were verified by Western blotting.
Limitations
- Column-level documentation is absent; field semantics must be inferred after download.
- Row count is unknown, which may limit suitability assessment.
- The dataset is 11.6 KB, indicating a limited scope of data.
Provenance
- Source
- figshare
- Collection Method
- Sequential window acquisition of all theoretical fragment ions (SWATH) proteomics performed on plasma exosomes.
- Freshness
- Last updated 2026-04-10 06:00:51; freshness should be verified.