Plasma Exosomal Proteins in Intrahepatic Cholestasis of Pregnancy

SWATH proteomics data from plasma exosomes of 35 pregnant women, including 10 with moderate intrahepatic cholestasis, 10 with severe, and 15 healthy controls. The dataset contains 109 and 46 differentially expressed proteins identified in total exosomes and placenta-derived exosomes, respectively. Author Yuxuan Jiang published the data on figshare in April 2026.

Use Cases

• Identify diagnostic protein markers for intrahepatic cholestasis of pregnancy based on differentially expressed proteins.
• Analyze complement activation and blood coagulation pathways in pregnancy disorders based on bioinformatics findings.
• Validate hub proteins like HRG, VWF, and PIGR as potential targets for stratified intervention.
• Investigate fetal stress response mechanisms linked to elevated maternal bile acids.
• Study placental exosome involvement in disease pathogenesis based on PIGR upregulation.

Strengths

• SWATH proteomics identified 109 differentially expressed proteins in total exosomes and 46 in placenta-derived exosomes.
• Data is derived from plasma samples of 35 pregnant women, including 10 moderate ICP, 10 severe ICP, and 15 healthy controls.
• Hub proteins HRG, VWF, and PIGR were identified and verified by Western blotting.
• The dataset is licensed under CC-BY-4.0 for open use.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect bias inherent to the specific cohort studied.

Provenance

Source

figshare

Collection Method

Sequential window acquisition of all theoretical fragment ions (SWATH) proteomics performed on plasma exosomes.

Freshness

Last updated 2026-04-10 06:00:55.