Gut Microbiome and Metabolite Profiles of Hypertensive Patients from Two Chinese Cities

A cross-sectional study conducted between May and December 2024 analyzed fecal samples from 60 hypertensive patients in Daqing and Haikou, China. The dataset, created by Shuyue Liu and shared under CC-BY-4.0, includes results from shotgun metagenomic sequencing and untargeted metabolomics. It compares microbial composition and metabolite profiles between patients from middle-temperate and tropical climates.

Use Cases

• Identifying differentially abundant microbial genera associated with geographic location based on ALDEx2 analysis results.
• Analyzing dysregulated metabolic pathways, such as glycerophospholipid metabolism and ABC transporters, from metabolomic data.
• Building logistic regression models to discriminate patient groups based on microbial signatures, as indicated by the reported AUC of 0.8069.
• Investigating correlations between specific differential microbes (e.g., Pseudescherichia) and metabolites (e.g., 15-HETE, ginsenoside Rg3).

Strengths

• Includes data from 60 patient samples (28 from Daqing, 32 from Haikou) with paired metagenomic and metabolomic profiles.
• Analysis adjusted for potential confounders including age, BMI, smoking, and drinking status.
• Identifies 34 differentially abundant genera and 38 differentially abundant metabolites with specific examples named.

Limitations

• Row count and specific column-level documentation are absent; field semantics must be inferred after download.
• The dataset is small at 15.5 KB, indicating a limited scope focused on summary or differential analysis results rather than raw sequence data.
• Data may reflect geographic and sampling bias inherent to the two specific cities studied.

Provenance

Source

Shuyue Liu via figshare.

Collection Method

Fecal samples analyzed using shotgun metagenomic sequencing and untargeted metabolomics from a cross-sectional study.

Time Range

Samples collected between May and December 2024.

Freshness

Last updated 2026-05-22 05:37:09; freshness should be verified.

Geography

Daqing (middle-temperate climate) and Haikou (tropical climate), China.