QFM-3m Compound Activity Data for LPS-Induced Acute Lung Injury

Yuxi Wang published this dataset on figshare in April 2026. It contains experimental results for a novel dihydrofurobenzofuran derivative, QFM-3m, tested in a lipopolysaccharide-induced acute lung injury model. The data likely includes in vitro and in vivo measurements of cytokine expression, histopathology, and protein analysis related to MAPK pathway inhibition.

Use Cases

• Modeling the relationship between compound structure and anti-inflammatory activity based on the screening of rhodomentosone-like derivatives.
• Analyzing cytokine suppression patterns (IL-1a, IL-1β, IL-6, TNF-α) in LPS-stimulated macrophages based on in vitro assay results.
• Evaluating lung-protective effects based on histopathology, cytokine assays, and vascular permeability analysis from the murine ALI model.
• Investigating selective MAPK pathway inhibition (ERK, JNK, p38) versus NF-κB activation based on transcriptomic and protein analysis data.

Strengths

• Dataset is 5.9 MB in size, indicating a focused and manageable download.
• Published under a CC-BY-4.0 license, permitting broad reuse with attribution.
• Includes results from multiple experimental modalities: in vitro screening, in vivo murine model, and mechanistic transcriptomic/protein analysis.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset's specific temporal and geographic coverage for the source material is not stated.

Provenance

Source

Yuxi Wang

Collection Method

Experimental data from screening compounds in LPS-stimulated RAW264.7 macrophages and testing in a murine acute lung injury model.

Time Range

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Freshness

Last updated 2026-04-21 04:13:00; freshness should be verified.

Geography

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