PyCryPH2 Protein Disruption Effects on Plasmodium Sporozoite Infectivity

Mayumi Tachibana's research data, last updated May 2026, investigates a novel crystalloid protein in Plasmodium yoelii. The dataset likely contains experimental results showing that disruption of the pycryph2 gene leads to irregular crystalloid microstructure and significantly reduces sporozoite invasion of mosquito salivary glands and mouse liver. These findings indicate the protein's role in forming well-organized crystalloids and maturing functional sporozoites.

Use Cases

• Analyzing the impact of gene disruption on crystalloid microstructure based on the described irregular particle arrangement.
• Modeling the relationship between crystalloid protein function and sporozoite infectivity based on the reduced invasion capability.
• Comparing the roles of paralogous crystalloid proteins (CryPH and CryPH2) in Plasmodium development.

Strengths

• Data is associated with a specific, peer-reviewed research finding on a novel Plasmodium protein.
• Dataset is openly available under a CC-BY-4.0 license, facilitating reuse.
• File size of 354.7 KB suggests a focused, manageable dataset.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset's scope is limited to a single protein (PyCryPH2) in one Plasmodium species (yoelii).

Provenance

Source

figshare, author Mayumi Tachibana

Collection Method

Likely contains experimental data from targeted gene disruption studies in Plasmodium yoelii.

Freshness

Last updated 2026-05-18 05:53:47; freshness should be verified.