Geraniin and Ulcerative Colitis: Multi-Omics and In Vivo Analysis Results

A preclinical dataset from 2026 investigating the natural compound geraniin in a mouse model of ulcerative colitis. It integrates multi-omics analyses from public transcriptomic databases with in vivo experimental results, including disease activity scores and immunofluorescence markers. The data was authored by Chang Cheng and shared under a CC-BY-4.0 license.

Use Cases

• Validate potential drug targets for ulcerative colitis based on the 27 geraniin-targeted genes identified.
• Analyze inflammatory pathway associations, such as IL-17 and TNF signaling, suggested by KEGG enrichment results.
• Investigate macrophage and neutrophil subpopulation targeting using single-cell AUCell scores from the GSE214695 dataset.
• Correlate molecular markers like NOS2 and PPARG expression with in vivo disease activity index (DAI) scores.

Strengths

• Integrates multiple analysis methods, including differential gene analysis, WGCNA, and single-cell Seurat analysis.
• Includes in vivo experimental results from a controlled murine model with three treatment groups.
• Data is shared under a permissive CC-BY-4.0 license for reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 11.2 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Analysis of public GEO datasets (GSE47908, GSE214695) combined with original in vivo experiments on DSS-induced colitis mice.

Freshness

Last updated 2026-05-13 04:48:18; freshness should be verified.