Proteome-Wide Atlas of Humoral Immunity to Mycobacterium tuberculosis

A proteome-wide atlas mapping antibody specificities across the spectrum of Mycobacterium tuberculosis infection outcomes. The dataset was authored by Mehak Z. Khan and last updated on June 3, 2026. It likely contains antibody binding data for Mtb proteins across different human and non-human primate populations.

Use Cases

• Identify promising Mtb protein vaccine candidates based on antibody binding patterns.
• Compare humoral immune responses across latent infection, active TB, and resistant populations.
• Investigate correlations between antibody binding to surface/secreted proteins and enhanced antibody functions.
• Guide the design of TB interventions aimed at mitigating disease globally.

Strengths

• Data is derived from a proteome-wide Mycobacterium tuberculosis microarray.
• Covers a spectrum of infection outcomes, including latent infection, active TB, and IGRA-resistant individuals.
• Includes data from both human subjects and non-human primate models.
• Released under a permissive CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (54.1 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Data likely generated using a proteome-wide Mtb microarray to map antibody specificities.

Freshness

Last updated 2026-06-03 04:51:00; freshness should be verified.