Proteomic Data on PDHK1 Expression in Aged Murine T Cells

Rajkumar S. Kalra published a dataset on figshare in 2026 analyzing the molecular basis of impaired T cell responses in aging. The data likely contains proteomic measurements from murine T cells, identifying pyruvate dehydrogenase kinase 1 (PDHK1) as significantly downregulated in aged cells. The dataset is 827.7 KB in size and is available under a CC-BY-4.0 license.

Use Cases

• Analyze age-related changes in glycolytic enzyme expression based on proteomic data.
• Model the relationship between PDHK1 levels and T cell activation states.
• Validate findings on PDHK1's role in T cell function using the provided experimental data.

Strengths

• Dataset is derived from data-independent acquisition (DIA) mass spectrometry, a precise proteomic method.
• Findings are validated across CD4+ and CD8+ T cell subsets and activation states.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect bias inherent to the specific murine model used.

Provenance

Source

Rajkumar S. Kalra via figshare

Collection Method

Data-independent acquisition (DIA) mass spectrometry-based proteomic analysis of murine T cells.

Freshness

Last updated 2026-05-11 14:41:01; freshness should be verified.