Gene Expression Patterns Modulated by TB Pleural Effusion Exosomal miRNAs

Five differentially expressed miRNAs and 54 differentially expressed genes were identified in a study modeling TB-associated lung cancer. The dataset likely contains results from network analysis linking these regulators to pathways like oxidative phosphorylation and ribosome biogenesis. Author Goeun Park published this 9.7 KB Excel file on figshare under a CC-BY-4.0 license in May 2026.

Use Cases

• Validate miRNA-mRNA regulatory networks based on the identified 5 DEMs and 54 DEGs.
• Perform pathway enrichment analysis based on the described links to oxidative phosphorylation and ribosome biogenesis.
• Investigate the role of specific cancer-related genes (NDUFA4, RPS27, COX7A2) in TB-associated lung cancer models.
• Reconstruct the potential regulatory framework connecting TB-derived exosomal miRNAs to lung cancer pathogenesis.

Strengths

• Specific counts of identified regulators are provided: 5 DEMs and 54 DEGs.
• The description details a clear methodological pipeline from exosome isolation to in vitro validation.
• The dataset is published under a permissive CC-BY-4.0 license.

Limitations

• Row count and column-level documentation are unknown, limiting suitability assessment.
• The dataset is very small at 9.7 KB, indicating a limited scope of results.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, author Goeun Park.

Collection Method

Generated from a study involving exosome isolation from tuberculous pleural effusion, injection into lung cancer xenograft mice, and subsequent miRNA/gene expression analysis.

Freshness

Last updated 2026-05-28 22:03:25; freshness should be verified.