ANCA-Associated Vasculitis Cardiovascular Risk: Propensity-Matched U.S. Cohort Study

A U.S.-based retrospective cohort study from the TriNetX network, analyzing 26,329 patients with granulomatosis with polyangiitis or microscopic polyangiitis and matched controls. The dataset, created by Sebastian Klapa and last updated in April 2026, reports hazard ratios for mortality and cardiovascular events like MACE and thromboembolism.

Use Cases

• Calculate hazard ratios for mortality and cardiovascular events based on reported propensity-matched cohorts.
• Compare cardiovascular risk profiles between granulomatosis with polyangiitis and microscopic polyangiitis based on the study's findings.
• Model the association between ANCA-associated vasculitis and specific outcomes like major adverse cardiovascular events or thromboembolic events.
• Validate propensity score matching methodologies for retrospective cohort studies in electronic health record data.

Strengths

• Includes 26,329 patient records (20,422 GPA and 5,907 MPA) from a U.S. electronic health records network.
• Reports specific hazard ratios for mortality (HR 3.01) and cardiovascular events (e.g., MACE HR up to 2.24).
• Uses a 1:1 propensity-matched control cohort for demographic variables and comorbidity.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the underlying data is unknown, which may limit suitability assessment.
• Data may reflect geographic and healthcare system bias inherent to the U.S.-based TriNetX network.

Provenance

Source

TriNetX network electronic health records database.

Collection Method

Retrospective cohort study with propensity score matching.

Time Range

null

Freshness

Last updated 2026-04-15 05:45:57; freshness should be verified.

Geography

United States