Table 2_Antibiotic resistance in Aeromonas hydrophila associated with exposure to subthera

Three independent bacterial lineages rapidly developed oxytetracycline resistance after 3 days of exposure, showing consistent adaptation patterns. Whole-genome sequencing identified recurrent point mutations in genes AHA_2785, AHA_2910, and AHA_0308, while transcriptomic analysis revealed over 1,000 differentially expressed genes. This dataset by Ju Zhang, last updated in May 2026, documents genetic and transcriptional changes driving antimicrobial resistance in an aquatic environment.

Use Cases

• Modeling the genetic basis of antibiotic resistance based on identified point mutations in specific genes.
• Analyzing coordinated pathway changes in efflux pumps, outer membrane proteins, and ribosomal proteins based on transcriptomic data.
• Studying the timeline of resistance development based on the observation of resistance starting after 3 days of incremental exposure.
• Investigating the risks of in-feed antibiotic usage in aquaculture based on the described experimental findings.

Strengths

• Includes both whole-genome sequencing and transcriptomic analysis data, providing a multi-omics perspective.
• Results are based on three independent bacterial lineages, suggesting reproducibility of the adaptation patterns.
• Transcriptomic analysis identified over 1,000 differentially expressed genes, indicating a substantial transcriptional response.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for specific modeling tasks.
• The 1.3 MB file size suggests the dataset is relatively small, potentially limiting the scope of analysis.

Provenance

Source

figshare

Collection Method

Experimental monitoring of genetic and transcriptional changes in Aeromonas hydrophila exposed to incremental oxytetracycline doses.

Time Range

Experimental timeline includes monitoring starting after 3 days of exposure.

Freshness

Last updated 2026-05 08 05:30:15; freshness should be verified.

Geography

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