Table 2_Antimicrobial effectiveness of intracanal medicaments against Enterococcus faecali

Twelve studies were included in a systematic review evaluating the antimicrobial effectiveness of intracanal medicaments against Enterococcus faecalis. The review, authored by Carlos M. Ardila and last updated in May 2026, employed a structured domain-based interpretative synthesis and exploratory meta-analysis. Antibiotic-based medicaments, particularly triple antibiotic paste, showed comparatively stronger antimicrobial performance in the available experimental evidence.

Use Cases

• Compare the efficacy of antibiotic-based medicaments versus calcium hydroxide based on the structured synthesis of in vitro, ex vivo, and clinical studies.
• Identify patterns of bacterial resistance and tolerance to intracanal medicaments based on the domain-based interpretative synthesis.
• Assess the potential of novel agents, including nanoparticle-based systems, based on the review's findings of promising but heterogeneous results.
• Inform the design of future standardized clinical investigations based on the review's conclusions about evidence limitations.

Strengths

• Follows PRISMA 2020 guidelines for systematic review methodology.
• Includes a structured domain-based interpretative synthesis across key domains.
• Registered with PROSPERO under identifier CRD420261345958.

Limitations

• Quantitative meta-analysis was limited to only two studies due to extreme heterogeneity.
• The overall certainty of evidence from the included studies ranged from low to moderate.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

Carlos M. Ardila via figshare.

Collection Method

Systematic review of studies from PubMed/MEDLINE, Scopus, and Embase.

Freshness

Last updated 2026-05-29 06:07:45; freshness should be verified.