Table 2_ANXA2: Multi-Omics Data on Neuronal Pyroptosis After Intracerebral Hemorrhage

Qingyuan Wu published a dataset on figshare in 2026 containing multi-omics data from a study of intracerebral hemorrhage in mice. The 1.6 MB Excel file likely contains transcriptomic and proteomic profiling results used to identify Annexin A2 (ANXA2) as a hub protein promoting NLRP3 inflammasome activation and neuronal pyroptosis. The data supports the study's conclusion that ANXA2 is a key upstream regulator of secondary brain injury after hemorrhagic stroke.

Use Cases

• Validate the association between ANXA2 and NLRP3 based on co-immunoprecipitation data
• Analyze transcriptomic and proteomic changes in mouse brain tissue after intracerebral hemorrhage
• Investigate neuronal pyroptosis signaling pathways involving GSDMD cleavage and IL-1β/IL-18 secretion
• Correlate molecular findings with neurological function and brain pathology assessments

Strengths

• Data is derived from integrative transcriptomic–proteomic profiling, suggesting a multi-modal approach
• The dataset is associated with a study that includes in vivo functional validation via genetic knockdown
• The file size is 1.6 MB, indicating a focused dataset

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

Integrative transcriptomic–proteomic profiling of mouse ICH brain tissues with in vivo functional validation.

Freshness

Last updated 2026-05-26 04:39:08; freshness should be verified