Prostate Cancer APTw MRI Biomarkers and Gleason Score Correlation

Comprising quantitative imaging biomarker data from a study of 160 patients (86 with prostate cancer, 74 with benign prostatic hyperplasia). It compares amide proton transfer-weighted (APTw) MRI values with Apparent Diffusion Coefficient (ADC) values, PI-RADS v2.1 scores, and Gleason Scores (GS). The data was used to evaluate the diagnostic performance of APTw imaging for differentiating cancer from benign hyperplasia and assessing tumor aggressiveness.

Use Cases

• Analyze the correlation between APTw values and Gleason Score (GS) to assess tumor aggressiveness in prostate cancer.
• Compare APTw values between the PCa and BPH patient groups to evaluate diagnostic performance for differentiation.
• Assess the combined diagnostic model of APTw + PI-RADS v2.1 scores against PI-RADS v2.1 alone using ROC analysis.
• Perform subgroup analysis on APTw values for lesions in the Transition Zone (TZ) or patients in the PSA 'gray zone' (4–10 ng/mL).

Strengths

• Data is derived from a study of 160 patients, providing a clinical sample size.
• Includes comparison of APTw values with multiple established metrics: ADC values, PI-RADS v2.1 scores, and Gleason Scores.
• Results show a significant positive correlation (Spearman’s ρ = 0.407) between APTw values and Gleason Score.
• Study design includes challenging clinical subgroups like the PSA 'gray zone' for robustness assessment.

Limitations

• The dataset is very small at 9.4 KB, indicating limited scope and likely a summary table rather than raw patient-level data.
• Sample data and column structure are unavailable, limiting understanding of the data's granularity and format.
• As a retrospective study, the data may have inherent selection biases and does not establish causality.

Provenance

Source

figshare, authored by Jie Feng.

Collection Method

Retrospective study where 160 patients underwent 3.0T multi-parametric MRI, including APTw imaging.

Freshness

Last updated March 20, 2026.