Table 2_Association between circulating biomarkers of one-carbon metabolism and glymphatic

A study of 210 participants, including individuals with normal cognition, mild cognitive impairment due to Alzheimer's disease, and Alzheimer's dementia, conducted by Yali Chen and last updated in May 2026. It investigates the relationship between circulating biomarkers of one-carbon metabolism and glymphatic system function, as measured by the DTI-ALPS index, and their combined effects on cognitive performance.

Use Cases

• Analyze associations between serum folate levels and glymphatic function based on DTI-ALPS index measurements
• Investigate correlations between one-carbon metabolism biomarkers and domain-specific cognitive performance
• Compare cognitive outcomes between risk groups defined by biomarker and glymphatic function levels
• Explore subgroup differences in biomarker levels and glymphatic function based on sex and age

Strengths

• Includes data from 210 participants across three clinical groups
• Measures multiple biomarkers including serum folate, vitamin B12, and homocysteine
• Uses a neuroimaging-derived index (DTI-ALPS) to assess glymphatic function
• Reports statistically significant findings (e.g., p-values) for key associations

Limitations

• Dataset is small at 23.5 KB, suggesting limited scope
• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

Yali Chen via figshare

Collection Method

Clinical study enrolling participants and measuring circulating biomarkers and neuroimaging indices.

Freshness

Last updated 2026-05-11 04:29:12