Meta-Analysis of Dentition Defects and Alzheimer's Disease Risk, 1996-2022

A 2026 systematic review and meta-analysis by Qianxia Wang synthesizes 14 studies published between 1996 and 2022, with sample sizes ranging from 52 to 156,450 participants. The analysis found a significant association between dentition defects and increased Alzheimer's disease risk, with a pooled odds ratio of 1.38. The document is shared under a CC-BY-4.0 license.

Use Cases

• Assessing the pooled association between oral health and Alzheimer's disease risk based on the reported odds ratio.
• Analyzing heterogeneity in epidemiological study designs based on the reported I² statistic of 97%.
• Exploring potential mechanistic pathways like chronic inflammation or nutritional deficiencies mentioned in the results.
• Identifying gaps for future research based on the conclusion calling for high-quality prospective studies.

Strengths

• Follows PRISMA guidelines for systematic review and meta-analysis methodology.
• Includes 14 studies with a wide range of sample sizes, up to 156,450 participants.
• Reports specific statistical results, including a pooled odds ratio of 1.38 (95% CI: 1.09–1.74).

Limitations

• The dataset is a 348.0 KB DOCX document, which is a small text file rather than a structured data table.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for direct computational analysis.

Provenance

Source

Qianxia Wang via figshare.

Collection Method

Systematic review and meta-analysis of studies from PubMed, Embase, Web of Science, and Cochrane Library.

Time Range

Studies published between 1996 and 2022.

Freshness

Last updated 2026-04-20 05:23:16; freshness should be verified.

Geography

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