Platelet-to-Neutrophil Ratio and Asthma–COPD Overlap in 1,025 Chinese Patients

Lei Yang's dataset from a 2026 figshare upload contains cross-sectional clinical data for 1,025 participants. It includes 340 patients with asthma–COPD overlap (ACO), 372 with COPD, 348 with asthma, and 685 healthy controls. The data was used to analyze the association between the platelet-to-neutrophil ratio (PNR) and ACO risk.

Use Cases

• Train a binary classification model to predict ACO risk based on PNR and other clinical covariates.
• Conduct statistical analysis to validate the non-linear relationship between PNR and ACO, including the 61.17 threshold.
• Perform subgroup analysis to explore how associations differ across demographic or clinical groups.
• Benchmark the diagnostic performance of PNR using the reported AUC of 0.774 from ROC analysis.

Strengths

• Dataset includes 1,025 participants with a clear breakdown of 340 ACO, 372 COPD, 348 asthma, and 685 healthy control cases.
• Analysis adjusted for 12+ key covariates including age, sex, BMI, and smoking history.
• Statistical results are detailed, including an odds ratio of 0.964 and a Spearman correlation of -0.447.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic bias inherent to the single-country, cross-sectional study design.

Provenance

Source

Lei Yang via figshare.

Collection Method

Cross-sectional retrospective study using clinical data.

Freshness

Last updated 2026-03-18 07:07:57; freshness should be verified.

Geography

China