aMAP Score Association with Mortality in MASLD/MetALD/ALD Patients: NHANES 1999-2018

32,654 participants from the U.S. National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018 were analyzed in a cohort study by Peng-yang Li. The research assesses the association between the aMAP risk score and all-cause, cardiovascular, and cancer mortality in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), MetALD, and Alcohol-related Liver Disease (ALD). Findings were externally validated using an independent hospital-based Southern Chinese cohort of 642 individuals.

Use Cases

• Validate the aMAP risk score as a non-invasive mortality predictor based on the described cohort study methodology.
• Model long-term mortality risk stratification for steatotic liver disease patients based on the reported hazard ratios.
• Conduct external validation of clinical risk scores using independent cohorts based on the described validation approach.

Strengths

• Includes a large primary cohort of 32,654 participants from a nationally representative survey (NHANES).
• Provides external validation using an independent hospital-based cohort of 642 individuals.
• Analyzes multiple mortality outcomes (all-cause, cardiovascular, cancer) and uses advanced statistical models (Cox, Fine-Grey).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the primary data table is unknown, which may limit suitability assessment.
• The 19.2 KB file size suggests the dataset is likely a summary table or document, not the raw patient-level data.

Provenance

Source

National Health and Nutrition Examination Survey (NHANES) and an independent hospital-based Southern Chinese cohort.

Collection Method

Cohort study using multivariable Cox models, Restricted cubic spline analysis, and Kaplan–Meier curves.

Time Range

Primary data from NHANES cycles 1999 to 2018, with mortality follow-up through December 31, —2019.

Freshness

Last updated 2026-04-24 13:49:22; freshness should be verified.

Geography

United States (primary cohort) and Southern China (validation cohort).