Serum Active IL-18 Levels in Adult-Onset Still's Disease with Clinical Correlations

47 untreated patients with adult-onset Still's disease (AOSD) were studied alongside 42 rheumatoid arthritis patients, 9 familial Mediterranean fever patients, and 26 healthy controls. This dataset, authored by Shu Yoshida and shared under CC-BY-4.0, contains measurements of serum active IL-18 and 69 other cytokines, correlated with clinical parameters like the Pouchot score and HScore. It was last updated on 2026-04-28.

Use Cases

• Evaluate the diagnostic accuracy of active IL-18 for adult-onset Still's disease based on the reported sensitivity and specificity.
• Analyze correlations between cytokine profiles and clinical disease activity scores like the HScore mentioned in the description.
• Investigate associations between biomarker levels and specific clinical features such as rash and splenomegaly.
• Compare inflammatory biomarker levels across different disease groups (AOSD, RA, FMF) and healthy controls.

Strengths

• Includes data from 124 total subjects across four distinct cohorts (AOSD, RA, FMF, healthy controls).
• Reports a high diagnostic accuracy for active IL-18 with an area under the curve of 0.963.
• Correlates biomarker levels with multiple clinical parameters, including the Pouchot score and serum ferritin.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 17.9 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Serum samples were analyzed using specific ELISA and multiplex suspension array techniques.

Freshness

Last updated 2026-04-28 05:24:16; freshness should be verified.