Table 2_Association of NDRG4 gene methylation in peripheral blood leukocytes with gastric

A two-phase case-control study of 310 gastric cancer patients and 300 controls analyzed the association between NDRG4 gene methylation in peripheral blood leukocytes and cancer risk, chemotherapy efficacy, and prognosis. The dataset includes results from bioinformatics analysis of NDRG family genes using TCGA and GEO databases, as well as comparisons of methylation levels across rs7202037 SNP genotypes. It was authored by Zhan Li and last updated on 2026-04-27.

Use Cases

• Identifying epigenetic biomarkers for gastric cancer risk based on NDRG4 methylation at specific CpG sites.
• Predicting chemotherapy efficacy in gastric cancer patients using methylation data from peripheral blood leukocytes.
• Analyzing the association between genetic variation (rs7202037) and methylation levels of the NDRG4 gene.
• Investigating the relationship between NDRG4 gene expression and its methylation status in a clinical cohort.

Strengths

• Includes data from a two-phase case-control study with 610 total participants (310 patients, 300 controls).
• Reports specific odds ratios and confidence intervals for associations between methylation at two CpG sites and gastric cancer risk.
• Links methylation data to clinical outcomes like progression-free survival and chemotherapy efficacy with reported p-values.

Limitations

• The dataset is very small at 17.3 KB, suggesting limited raw data or a summary document.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale modeling.

Provenance

Source

figshare, authored by Zhan Li.

Collection Method

Bioinformatics analysis of TCGA and GEO databases combined with a two-phase case-control study.

Freshness

Last updated 2026-04-27 04:12:22; freshness should be verified.