Berberine Modulation of MRSA Virulence Gene Expression via Agr System

A 10.7 KB dataset by Fangfang Zhou, last updated April 28, 2026, contains qRT-PCR results from a study on the natural compound berberine. The data likely includes measurements of gene expression for virulence factors like α-Hemolysin (Hla), Phenol-soluble modulin α (psmα), and Clumping factor A (clfA) in methicillin-resistant Staphylococcus aureus (MRSA).

Use Cases

• Analyze the correlation between berberine concentration and suppression of Agr system activity based on qRT-PCR data.
• Model the relationship between Agr system inhibition and downregulation of specific virulence genes (hla, psmα, clfA) mentioned in the description.
• Validate phenotypic assay predictions (hemolytic activity, biofilm formation) using the underlying gene expression data.

Strengths

• Data is openly licensed under CC-BY-4.0.
• File size is 10.7 KB, indicating a focused and manageable dataset for analysis.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

figshare

Collection Method

Data generated from quantitative Real-time polymerase chain reaction (qRT-PCR) experiments and phenotypic assays.

Freshness

Last updated 2026-04-28 05:27:57; freshness should be verified.