Bioinformatics Analysis of Bushen Anzhi Recipe for Aging-Related Insomnia

A study analyzing the mechanisms of a traditional Chinese medicine formula for insomnia. The dataset includes bioinformatics analysis of 555 human samples from the GEO database (GSE98582) and experimental results from a rat model study involving 60 animals. The research was authored by Haiming Li and shared on figshare under a CC-BY-4.0 license.

Use Cases

• Identify potential drug targets for insomnia based on overlapping neuroinflammatory targets.
• Analyze gene expression patterns associated with aging-related insomnia using the GSE98582 dataset.
• Investigate the regulatory effects of herbal compounds on pathways like Wnt signaling.
• Validate bioinformatics predictions with in-vivo experimental measures like sleep time and protein levels.

Strengths

• Includes data from 555 human gene expression samples (GSE98582).
• Integrates multi-source data from GeneCards, MSigDB, TCMSP, and HERB databases.
• Validates computational findings with in-vivo rat model experiments involving 60 subjects.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The dataset is very small at 10.9 KB, indicating limited scope or summary-level data.

Provenance

Source

Gene Expression Omnibus (GEO) database, Traditional Chinese Medicine Systems Pharmacology (TCMSP) database, HERB database, and experimental rat models.

Collection Method

Bioinformatics analysis of public gene expression data combined with targeted experimental validation in a rodent model.

Freshness

Last updated 2026-05-08 05:54:40; freshness should be verified.