Table 2: BRCA Testing Patterns in U.S. Breast Cancer Patients, 2000s-2024

Kathryn Mishkin's literature review summarizes 35 publications up to September 2024 on real-world BRCA germline mutation testing patterns in U.S. breast cancer patients. The review includes 32 unique studies and reports testing increases ranging from 7% to 47% since the early 2000s. It also documents barriers to testing such as cost, insurance coverage, and limited patient knowledge.

Use Cases

• Analyzing temporal trends in BRCA testing adoption based on the reported 7%-47% increases over time
• Identifying systemic barriers to genetic testing based on documented issues like cost, insurance, and guideline clarity
• Benchmarking testing rates in specific patient subgroups like those with hormone receptor-positive early breast cancer
• Studying knowledge gaps and attitudes toward genetic testing based on reported patient and physician misconceptions

Strengths

• Synthesizes evidence from 35 publications representing 32 unique studies
• Provides specific quantitative ranges for testing increases (7% to 47%)
• Explicitly documents multiple concrete barriers (cost, insurance, knowledge gaps)

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download
• The majority of included studies had data collection periods prior to 2020, limiting recency
• Dataset is a 672.6 KB DOCX file, indicating a limited textual summary rather than primary data

Provenance

Source

Kathryn Mishkin via figshare

Collection Method

Targeted literature review of published studies

Time Range

Studies from early 2000s up to September 2024

Freshness

Last updated 2026-04-27 04:14:38; freshness should be verified as the underlying review covers literature up to September 2024.

Geography

United States