PP1 Analogs: Cellular Effects on Non-Tumoral and Tumoral Cell Lines

A 10.6 KB Excel file uploaded by Coralie Gicquel to figshare on 2026-04-28. It contains data on the effects of five bulky PP1 analog inhibitors on cellular processes like migration, invasion, proliferation, and viability. The work examines these effects in cell lines that do not express an analog-sensitive kinase.

Use Cases

• Assessing inhibitor specificity based on cellular effect concentrations mentioned in the description
• Comparing the impact of different PP1 analogs on cell migration and invasion potential
• Evaluating the relationship between inhibitor concentration and effects on cell cycle and differentiation
• Identifying suitable inhibitor concentrations for studies aiming to minimize non-specific effects

Strengths

• Data is shared under a permissive CC-BY-4.0 license.
• The description provides specific concentration thresholds (≥5 µM, 2 µM) for interpreting cellular effects.
• The dataset focuses on a specific, well-defined chemical genetics problem.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (10.6 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from cell biology assays.

Freshness

Last updated 2026-04-28 10:21:04; freshness should be verified.