CIRC Tumor Case Report: Genomic and Immunohistochemistry Data

A single-case dataset from a 67-year-old female patient with a rare cytokeratin-positive interstitial reticulum cell tumor. Wen Liu published this case report on figshare in 2026, detailing genomic sequencing, immunohistochemistry results, and the first identification of HLA loss of heterozygosity in this tumor type. The data is contained in a 58.0 KB Excel file.

Use Cases

• Study the genomic landscape of a rare fibroblastic reticular cell tumor based on whole-exome sequencing data for single-nucleotide variants, indels, and copy number gains.
• Analyze potential immune evasion mechanisms based on the reported HLA loss of heterozygosity events affecting HLA-B39:01:01:01 and HLA-C07:02:01:01.
• Correlate histopathological features with molecular findings based on described immunohistochemistry markers (e.g., cytokeratins, CD68, Ki-67 index) and genomic instability.
• Investigate therapeutic implications for immunotherapy based on the described HLA LOH and its suggested impact on checkpoint inhibitor efficacy.

Strengths

• Includes detailed molecular profiling from whole-exome sequencing, identifying 30 single-nucleotide variants and 7 indels.
• Provides comprehensive immunohistochemistry results for over 15 markers, including Ki-67 proliferation index of 25%.
• Documents a novel finding of HLA loss of heterozygosity, a first for this tumor subtype.
• Case includes longitudinal data with details on a local recurrence seven years after initial resection.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is from a single case report, limiting statistical power and generalizability.

Provenance

Source

figshare

Collection Method

Clinical case report with genomic and histopathological analysis.

Freshness

Last updated 2026-06-02 04:21:00; freshness should be verified.