Case Report: Primary Acute Mast Cell Leukemia with FGFR1 Rearrangement

A single case report details a rare presentation of primary acute mast cell leukemia. The document describes a patient who tested negative for common KIT gene mutations but exhibited an FGFR1 gene rearrangement. Authored by Yalu Liu, this 14.9 KB document was last updated on May 7, 2026.

Use Cases

• Studying atypical genetic markers in aggressive mast cell leukemia based on the reported FGFR1 rearrangement.
• Analyzing clinical presentation and treatment response based on the described case of intractable shock and bone destruction.
• Reviewing molecular insights for novel therapeutic targets in mastocytosis based on the documented use of an FGFR1 inhibitor.

Strengths

• Document is licensed under CC-BY-4.0, permitting open sharing and adaptation.
• The case report is the first to document an FGFR1 gene rearrangement in mast cell leukemia, providing a novel molecular insight.

Limitations

• The dataset consists of a single case report, offering limited statistical power for generalizable conclusions.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare, authored by Yalu Liu.

Collection Method

Likely contains a detailed clinical case study and analysis.

Freshness

Last updated 2026-05-07 04:46:22; freshness should be verified.