Cerebrospinal Fluid Proteomics for Hydrocephalus Biomarker Discovery

An exploratory proteomic study of cerebrospinal fluid samples from 11 participants, including patients with post-hemorrhagic hydrocephalus, idiopathic normal pressure hydrocephalus, and non-hydrocephalus controls. The dataset, authored by Hao Han and last updated in May 2026, contains normalized protein expression values analyzed via Olink proximity extension assay. It identifies calcyphosine and follistatin-like 1 as exploratory candidate proteins of interest.

Use Cases

• Identify differentially expressed proteins in hydrocephalus subtypes based on proteomic profiles.
• Validate exploratory candidate biomarkers like calcyphosine and follistatin-like 1 in independent cohorts.
• Perform functional annotation analysis based on pathways related to inflammation, synaptic signaling, and neural connectivity mentioned in the description.
• Compare cerebrospinal fluid proteomic signatures between post-hemorrhagic and idiopathic normal pressure hydrocephalus.

Strengths

• Proteomic data analyzed using the Olink proximity extension assay, a specific high-throughput method.
• Includes validation of key findings via ELISA in an expanded cohort, as described.
• All samples passed quality-control criteria as stated in the results.
• Released under a CC-BY-4.0 license, permitting open reuse with attribution.

Limitations

• Small cohort size of 11 participants, as explicitly stated in the methods.
• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The exploratory nature of the study requires validation in larger, independent cohorts as noted in the discussion.

Provenance

Source

figshare

Collection Method

Cerebrospinal fluid samples analyzed using Olink proximity extension assay proteomics, with ELISA validation.

Freshness

Last updated 2026-05-29 07:14:56