Thyroid Cancer Prognostic Risk Model Based on Immune Gene Expression

A retrospective study of 180 thyroid cancer patients treated between May 2022 and April 2025, used to construct a prognostic risk model based on immune gene expression. The dataset, authored by Qi Qi and shared under a CC-BY-4.0 license, includes analysis of genes like CDK1, B3GNT7, S100A9, and MMP9, and their correlation with immune cell infiltration and clinical outcomes.

Use Cases

• Training a binary classification model to predict patient prognosis based on the expression levels of CDK1, B3GNT7, S100A9, and MMP9.
• Analyzing correlations between specific immune gene expression and the infiltration abundance of B lymphocytes, CD4+ T lymphocytes, and CD8+ T lymphocytes.
• Validating the prognostic performance of a logistic regression model using metrics like the C-index (0.919) and AUC (0.880) reported in the study.
• Investigating the relationship between high expression of S100A9 and MMP9 genes and advanced lymph node metastasis (pN stage) or distant metastasis (pM stage).

Strengths

• Includes a clearly defined cohort of 180 patients with thyroid cancer.
• Reports specific model performance metrics, including an average C-index of 0.919 and an AUC of 0.880.
• Identifies four specific immune genes (CDK1, B3GNT7, S100A9, MMP9) as independent risk factors with statistical significance (P < 0.05).

Limitations

• Row count and column-level documentation are unknown, which limits suitability assessment.
• The dataset is very small at 61.5 KB, suggesting limited scope or a summary document rather than raw patient-level data.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

figshare, author Qi Qi.

Collection Method

Retrospective clinical study of patients from a single hospital, supplemented with analysis from the TCGA-THCA database.

Time Range

Patient data from May 2022 to April 2025.

Freshness

Last updated 2026-04-22 22:01:10; freshness should be verified.