Pediatric Glucocorticoid Exposure and Cardiac Outcomes Review

A 2026 narrative review by Wenxuan Li synthesizes clinical evidence on childhood systemic glucocorticoid exposure and its links to cardiac structure and function alterations. The dataset, a 15.6 KB XLSX file, compiles findings on transient myocardial hypertrophy, subclinical functional impairment, and associations with cardiometabolic risk factors from pediatric studies.

Use Cases

• Extract structured evidence on glucocorticoid exposure associations with myocardial hypertrophy phenotype for meta-analysis.
• Analyze reported relationships between glucocorticoid dose–time metrics and intermediate cardiometabolic risk factors.
• Compile data on sensitive cardiac metrics like tissue Doppler parameters and myocardial performance index across pediatric conditions.
• Map evidence gaps for long-term outcomes such as heart failure and coronary events from pediatric-to-adult longitudinal data.

Strengths

• Synthesizes evidence from multiple pediatric conditions with repeated or prolonged systemic glucocorticoid use.
• Includes analysis of sensitive cardiac metrics like tissue Doppler and strain beyond conventional systolic indices.
• Explicitly addresses dose–time associations with intermediate cardiometabolic risk factors and thromboembolic events.
• Released under a permissive CC BY 4.0 license for reuse.

Limitations

• Very small data scale at 15.6 KB, indicating a summary table or extracted findings, not a primary research dataset.
• Evidence for persistent structural damage in older children is noted as sparse and confounded by underlying disease.
• Direct longitudinal data linking pediatric exposure to adult cardiovascular outcomes remains limited.

Provenance

Source

Wenxuan Li via figshare

Collection Method

Narrative review synthesizing representative clinical evidence from published studies.

Time Range

Covers studies up to the 2026 publication date.

Freshness

Last updated March 26, 2026.

Geography

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