Clinical Implications of ALDH1L1 Expression in Hormone Receptor-Positive Breast Cancer

A clinical research dataset from Seoul National University Hospital analyzes ALDH1L1 expression across 1,086 breast cancer cases. The study correlates protein expression levels with tumor characteristics and patient survival outcomes, particularly in hormone receptor-positive subtypes. Author Han Suk Ryu published the findings on figshare under a CC-BY-4.0 license.

Use Cases

• Identify prognostic biomarkers for breast cancer based on ALDH1L1 expression levels.
• Investigate subtype-specific survival correlations using clinical and immunohistochemistry data.
• Validate in vitro findings on ALDH1L1's cytotoxic effects with clinical patient outcomes.
• Explore associations between folate metabolism enzymes and tumor aggressiveness features like size and stage.

Strengths

• Includes data from 1,086 breast cancer cases across three cohorts, providing a substantial sample size.
• Correlates protein expression with multiple clinical endpoints, including overall survival, disease-free survival, tumor size, and stage.
• Findings were validated using an external database (METABRIC), supporting reproducibility.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic bias inherent to a single hospital source (Seoul National University Hospital).

Provenance

Source

Seoul National University Hospital

Collection Method

Immunostaining performed on tissue microarrays and whole section slides, with clinical data collected from patient records.

Freshness

Last updated 2026-05-25 04:33:59; freshness should be verified.

Geography

South Korea (Seoul)