Clinical Outcomes of Preimplantation Genetic Testing for Chromosomal Inversions, 2019-2024

A retrospective analysis of 27.3 KB of clinical data from couples undergoing preimplantation genetic testing (PGT) between January 2019 and December 2024. The study, authored by Yutong Li and shared under a CC-BY-4.0 license, compares euploid and aneuploid blastocyst rates across different genetic subgroups. Key findings include a significantly higher aneuploidy rate in couples with female inversion carriers and in those with pericentric inversions compared to paracentric inversions.

Use Cases

• Compare euploid blastocyst rates between couples with chromosomal inversions, polymorphic variations, and normal karyotypes based on the described subgroup analysis.
• Investigate the influence of carrier gender on aneuploidy rates in chromosomal inversion cases based on the reported statistical difference.
• Analyze the relationship between inverted fragment size and the proportion of aneuploid blastocysts based on the described linear trend.
• Evaluate the clinical outcomes of pericentric versus paracentric inversions based on the reported difference in aneuploid blastocyst proportions.

Strengths

• Data covers a specific six-year time range from January 2019 to December 2024.
• Analysis includes comparisons across four distinct clinical subgroups (PGT-INV, PGT-PV, PGT-A, PGT-SR).
• Findings report specific statistical results, such as a 38.94% aneuploid rate for pericentric inversions versus 23.60% for paracentric inversions.

Limitations

• The dataset is very small at 27.3 KB, indicating limited scope.
• Row count and column-level documentation are unknown, which limits suitability assessment.
• The primary data file is a DOCX document, which may require extraction or conversion for computational analysis.

Provenance

Source

figshare

Collection Method

Retrospective clinical study of couples who underwent PGT, with classification based on karyotyping analysis.

Time Range

January 2019 to December 2024

Freshness

Last updated 2026-04-24 09:13:35.