Clinical Practice Guidelines for Early Psychosis Intervention: AGREE II Appraisal

26 clinical practice guidelines and quality standards for early intervention in psychosis, published from 2005 onward, were systematically reviewed and appraised using the AGREE II methodology. The dataset, authored by Pasquale Scognamiglio and last updated in June 2026, identifies 32 core recommendations for treating clinical high-risk and first-episode psychosis populations. It is a 16.5 KB document summarizing the review's methodology, quality appraisal results, and synthesized service components.

Use Cases

• Benchmarking local clinical protocols against internationally endorsed service components for psychosis intervention.
• Informing the development of new clinical practice guidelines based on synthesized recommendations for assessment and treatment.
• Analyzing methodological quality and gaps in existing guidance using AGREE II domain scores reported in the review.

Strengths

• Systematic methodology following PRISMA 2020 guidance, with a review protocol registered on OSF.
• Appraises 26 documents (24 clinical practice guidelines and 2 quality standards) using the standardized AGREE II tool.
• Identifies 32 core recommendations derived from documents that met specific endorsement criteria.

Limitations

• The dataset is a 16.5 KB summary document; the underlying primary guideline documents are not included.
• Row count and column-level documentation for any extracted data are unknown.
• Scope is limited to documents published in English or Italian from 2005 onward, which may introduce language and recency bias.

Provenance

Source

Systematic review of MEDLINE, Cochrane Library, Web of Science, guideline repositories, and grey literature.

Collection Method

Documents were identified via systematic search, appraised with AGREE II, and recommendations were extracted and synthesized.

Time Range

Guidelines published from 2005 to March 2025.

Freshness

Last updated 2026-06-03 06:02:26

Geography

International (guidelines and standards from multiple jurisdictions).