Cocaine-Induced m6A RNA Methylation and Locomotor Plasticity Data in Drosophila

26.7 KB of data from a study investigating how volatilized cocaine exposure reshapes m6A RNA methylation and related signaling in Drosophila melanogaster. The dataset, authored by Ana Filošević Vujnović and last updated in April 2026, integrates results from RNA-seq and MeRIP-seq analyses to link epitranscriptomic changes to behavioral plasticity.

Use Cases

• Analyze cocaine-induced changes in m6A modification levels across coding and non-coding RNA species based on MeRIP-seq data.
• Investigate the role of m6A readers (YTHDC, YTHDF) in locomotor sensitization based on genetic and cell-type-specific analyses.
• Compare m6A-modified RNA classes, such as antisense RNAs and transposable elements, between control and cocaine-exposed conditions.
• Study the enrichment of m6A-modified RNAs in core metabolic pathways like oxidative phosphorylation in control samples.

Strengths

• Data is derived from integrated RNA-seq and MeRIP-seq analyses, providing a multi-omics perspective.
• Includes genetic and cell-type-specific (neurons vs. glia) analyses of m6A pathway components.
• Licensed under CC-BY-4.0, permitting open sharing and adaptation.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 26.7 KB file size suggests a limited, likely summary-level dataset rather than raw sequencing data.

Provenance

Source

figshare, author Ana Filošević Vujnović.

Collection Method

Experimental data from Drosophila melanogaster exposed to volatilized cocaine, analyzed via RNA-seq and MeRIP-seq.

Time Range

Experimental timeframe not specified; dataset reflects a specific study.

Freshness

Last updated 2026-04-15 04:37:05; freshness should be verified.

Geography

Laboratory study; no geographic coverage.