Table 2_Comparative efficacy and safety of ursodeoxycholic acid, fibrates, and combination

An umbrella meta-analysis synthesizing results from 23 meta-analyses and 45 unique randomized controlled trials involving 3,276 patients with primary biliary cholangitis. The document compares biochemical outcomes and adverse events for ursodeoxycholic acid, fibrates, and combination therapy. It was authored by Jian Zhang and last updated in May 2026.

Use Cases

• Compare treatment efficacy for primary biliary cholangitis based on biochemical response rates mentioned in the description
• Assess safety profiles of drug therapies based on reported adverse event rates
• Evaluate the methodological quality of existing meta-analyses in this clinical domain based on the AMSTAR 2 assessment
• Inform clinical guideline development for liver disease management based on synthesized evidence from multiple meta-analyses

Strengths

• Synthesizes evidence from 23 meta-analyses and 45 unique randomized controlled trials
• Reports specific quantitative outcomes, such as mean differences in alkaline phosphatase and bilirubin levels with confidence intervals
• Assesses methodological quality using the AMSTAR 2 tool and overlap using corrected covered area
• Includes data on 3,276 patients after removing duplicate records across studies

Limitations

• Description metadata is limited; actual data quality requires manual inspection after download
• Column-level documentation is absent; field semantics must be inferred after download
• The dataset is a 13.8 KB document, indicating a limited scope focused on summary results rather than raw trial data

Provenance

Source

figshare

Collection Method

Systematic review and umbrella meta-analysis of existing meta-analyses.

Time Range

Meta-analyses searched from database inception to 2025.

Freshness

Last updated 2026-05-25 04:33:17; freshness should be verified